Volume 51/Number 1/Abstract 10
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Acta Parasitologica, Vol. 51, No. 1, 2006, 73-78
Alicia Gomez-Barrio(1)*, David Montero-Pereira(1), Juan J. Nogal-Ruiz(1), Jose A. Escario(1), Susana Muelas-Serrano(1), Vladimir V. Kouznetsov(2), Leonor Y. Vargas Mendez(2), Juan M. Urbina GonzAles(2) and Carmen Ochoa(3) - Antiparasitic properties of homoallylamines and related compounds

(1)Departamento de Parasitologia, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain; (2)Laboratory of Fine Organic Synthesis, Research Center for Biomolecules, School of Chemistry, Industrial University of Santander, A.A. 678, Bucaramanga, Colombia; (3)Instituto de Quimica Medica (CSIC), Juan de la Cierva, 3, 28006 Madrid, Spain
*Corresponding author: agbarrio@farm.ucm.es
A study of some antiparasitic properties of several homoallylamines and related tetrahydroquinolines and quinolines, previously described, was carried out using in vitro activity assays against the epimastigote form of Trypanosoma cruzi and against Trichomonas vaginalis. Unspecific cytotoxicity against murine macrophages was also studied. Although the antichagasic and trichomonacidal activities are not comparable to those of the standard drugs, nifurtimox and metronidazole, some of the compounds exhibit an interesting specific antiparasitic activity.
KEY WORDS: Homoallylamines, tetrahydroquinolines, quinolines, antichagasic, trichomonacidal, unspecific cytotoxicity

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